Trophoblast Extracellular Vesicles as Modulators of Keratinocyte Stress Response and Senescence.

ABSTRACT: Keratinocyte stress, caused by various intrinsic and extrinsic factors, contributes to the overall aging process. D-galactose-induced metabolic/oxidative stress is a commonly used in vitro model for studying premature aging. Due to their rich composition of bioactive molecules that influence critical pathways in cellular aging and rejuvenation, placental derivatives have a well-established history in anti-aging skincare and therapy. However, trophoblast-derived extracellular vesicle (TEV) effects on D-galactose-induced premature aging in keratinocytes have not been investigated yet. TEV pretreatment for 24 h enhanced cellular resilience against D-galactose-induced stress, judging by the downregulated expression of senescence- and stress-associated markers (p19 and p21, HIF-1α, mTOR)

SUBMITTER: Nacka-Aleksic M 

PROVIDER: S-EPMC12194262 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature