Sex and Age Differences in Ketamine Efficacy and Safety in Chronic Pain Alleviation.

ABSTRACT: Background: Ketamine use for chronic pain and depression has increased worldwide, but sex differences in its efficacy and safety have been little studied; this study examines existing evidence to address this gap. Methods: A prospective, multicenter, one-year observational study in 585 chronic pain patients was performed; 256 patients had one administration of ketamine and 329 had two or more. The primary outcome looked at was mean pain intensity (0-10), assessed every month for 1 year by telephone. Secondary outcomes included measures of depression and anxiety (assessed using the Hospital Anxiety and Depression Scale), quality of life (evaluated with the 12-item Short Form Health Survey), total ketamine dosage, reported adverse effects, and concomitant treatments. Platform o

SUBMITTER: Pickering G 

PROVIDER: S-EPMC12194336 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature