Alteration of m⁶A Methylation in Breast Cancer Cells by <i>Kalanchoe pinnata</i> Aqueous Extract.

ABSTRACT: Kalanchoe pinnata is used in traditional medicine to treat cancer, as it contains flavonoids and phenols known to regulate key cellular processes associated with cancer. Breast cancer, the most common cancer among women globally, presents ongoing challenges in treatment. The discovery of m⁶A methylation and its regulation by methylosome proteins offers novel therapeutic avenues for cancer management. This study aimed to investigate the cytotoxic and epitranscriptomic effects of an aqueous extract from K. pinnata on MCF-7 (luminal A) and HCC1937 (triple-negative) breast cancer cells. Cell lines were treated with the aqueous K. pinnata extract, characterized by HPLC, for 72 h, followed by an assessment of cytotoxicity and migration. The expression of methyloso

SUBMITTER: Alvizo-Rodriguez CR 

PROVIDER: S-EPMC12195708 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature