Drug Pair of Astragali Radix-Ligustri Lucidi Fructus Alleviates Acute Kidney Injury in Mice Induced by Ischemia-Reperfusion Through Inhibiting Ferroptosis.

ABSTRACT: Background: Acute kidney injury (AKI), characterized by high morbidity and mortality, is primarily caused by renal ischemia-reperfusion injury (RIRI). Ferroptosis plays a key role in RIRI, yet its underlying mechanisms remain unclear. The drug pair of Astragali Radix-Ligustri Lucidi Fructus (DAL) shows promise in renal diseases, but its protective effects against RIRI and associated molecular pathways via ferroptosis inhibition are unknown. This study aimed to investigate DAL's therapeutic effects on RIRI and its mechanisms. Methods: A mouse model of bilateral renal ischemia-reperfusion was established. Renal function (serum creatinine, Scr; blood urea nitrogen, BUN), inflammatory cytokines (TNF-α, IFN-γ, IL-6), ferroptosis markers (GPX4, MDA, GSH, tissue iron), and pathologi

SUBMITTER: Liu X 

PROVIDER: S-EPMC12195751 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature