Synthesis, Molecular Docking and Biological Evaluation of A-Ring-Carborane-Vitamin D Analogues.

ABSTRACT: The active form of vitamin D₃, 1α,25-dihydroxyvitamin D₃ (1,25D₃), regulates a number of physiological and pathological processes, including cell proliferation and differentiation. Thousands of analogues of 1,25D₃ have been developed with the aim of selective effects for medical use. Here we describe the synthesis of two new unconventional vitamin D analogues bearing A-ring modifications with ortho-carborane (dicarba-o-closo-1,2-dodecaborane) units. The ligands function as agonists for VDR with similar antiproliferative activities as 1,25D₃. Whereas mice treated with the analogues 4 and 5 exhibited similar hypercalcemic activities as 1,25D₃, only compound 4 and 1,25D₃ indu

SUBMITTER: Otero R 

PROVIDER: S-EPMC12195832 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature