Transcriptome and Metabolome Analyses of <i>Taxus chinensis</i> var. <i>mairei</i> Tissues Provide New Insights into the Regulation of Paclitaxel Biosynthesis.

ABSTRACT: Taxus is the natural source of the anticancer drug paclitaxel. Although significant progress has been made in elucidating the biosynthetic pathway of paclitaxel, its tissue-specific accumulation and associated regulatory networks in Taxus remains unclear. In this study, we conducted integrated transcriptomic and metabolomic analyses of the root, leaf, shoot, bark, and wood of Taxus chinensis var. mairei to investigate the tissue-specific biosynthesis and accumulation of paclitaxel. We found that paclitaxel, 10-deacetylbaccatin III, and several taxoids were significantly enriched in the leaf, bark, and shoot, while paclitaxel derivatives, such as taxayunnansin A and taxol B, accumulated primarily in the root. Most genes involved in paclitaxel biosynthesis showed

SUBMITTER: Jiang L 

PROVIDER: S-EPMC12196951 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature