Intraretinal Electrophysiology and Resistivity Profiles of WT and RCS Rat Retina.

ABSTRACT: Retinal prostheses have been utilized in the treatment of blindness resulting from retinal degeneration. However, they have not met patient expectations, leading to market withdrawals. As a result, research continues to focus on improving visual perception, such as by modeling retinal neural activation. The retina's electrical resistivity profile is key, as it influences the current spread during electrical stimulation. To advance efficient stimulation parameters, more data on the electrical properties of the retina in both its healthy and diseased state is needed. While this question has been addressed in mouse models, few data are available from rat models, whose bigger size is advantageous for many applications. To address this knowledge gap, we used flexible penetrating microelectrode

SUBMITTER: Jung M 

PROVIDER: S-EPMC12197074 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature