Multidimensional Evaluation of Combined Anticoagulation and Venoprotective Therapy in Deep Vein Thrombosis: A Retrospective Propensity Score-Matched Cohort Study of Clinical, Economic, and Resource Utilization Outcomes.

ABSTRACT: Background: Deep vein thrombosis (DVT) management remains challenging despite standard anticoagulation therapy. This study evaluated the comprehensive benefits of combining rivaroxaban with Aescuven (CAV) compared to rivaroxaban monotherapy (SAT) in DVT treatment. Methods: A retrospective analysis was conducted on DVT patients (2018-2023) using multi-method propensity score matching and ensemble weighting. Outcomes included improvement rate (IPR), daily improvement rate (DIR), cost-effectiveness ratio (CER), daily improvement cost (DIC), cost-LOS efficiency (CLE), and length of stay (LOS). Counterfactual analysis was implemented to estimate causal effects. Results: The CAV group demonstrated superior outcomes compared to SAT: IPR increased by 6.39 percentage points (95

SUBMITTER: Zhou N 

PROVIDER: S-EPMC12197247 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature