Effects of Different Adjuvants on the Protective Efficacy of a Subcellular Vaccine Against <i>Chlamydia abortus</i> Infection in Sheep.

ABSTRACT:

Background/objective

Recently, we published three studies describing the development and optimization of a new, safe, and efficacious vaccine to protect sheep from ovine enzootic abortion, which is caused by the zoonotic pathogen Chlamydia abortus. The vaccine, which can be delivered through a single inoculation, is based on a detergent-extracted outer membrane protein (chlamydial outer membrane complex or COMC) preparation of the pathogen. This study aimed to optimize the vaccine further by comparing the effects of different adjuvants on protective efficacy.

Methods

We evaluated the effectiveness of three different vaccines (2.5 µg COMC) formulated with one of three adjuvants (Montanide ISA 70VG, Montanide ISA 61VG, and QuilA) to reduce the rate of abortion, placenta

SUBMITTER: Livingstone M 

PROVIDER: S-EPMC12197603 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature