Identification of Clinical and Genomic Features Associated with SARS-CoV-2 Reinfections.

ABSTRACT: Although SARS-CoV-2 reinfections remain a concern for healthcare systems worldwide, the factors driving them are still not fully understood. In this study, we examined data for 3303 individuals who experienced two SARS-CoV-2 infections between March 2020 and May 2022 from both clinical and viral genomics perspectives. Our findings indicate that viral evolution was the primary driver of reinfection. However, chronic conditions were common among reinfected individuals, including those under 26 years old, suggesting that the presence of underlying and/or chronic conditions increases susceptibility to reinfection. The median time elapsed between infections was one year, often coinciding with the emergence of new variants. While vaccination showed only a limited protective effect against reinfe

SUBMITTER: Munoz-Lopez F 

PROVIDER: S-EPMC12197629 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature