A food-sensitive olfactory circuit drives anticipatory satiety.

ABSTRACT: Food sensory perception has emerged as a potent regulator of specialized feeding circuits; yet, the consequences on feeding behaviour and the underlying neuronal basis remain poorly understood. Here, we reveal a sensory pathway that co-ordinately integrates food odours to control forthcoming nutrient intake in male mice. Unbiased whole-brain mapping of food odour-induced brain activity revealed a potent activation of the medial septum (MS), where food odours selectively activate MS glutamatergic neurons (MS^VGLUT2). Activity dynamics of MS^VGLUT2 neurons uncovered a biphasic modulation of their neuronal activity with a transient activation after detection of food odours and a long-lasting inhibition following food ingestion, independent of the caloric value and identity

SUBMITTER: Bulk J 

PROVIDER: S-EPMC12198014 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature