NIR light-propelled Janus Polydopamine@Mesoporous silica gene delivery nanomotor for the enhanced gene treatment of critical limb ischemia.

ABSTRACT: Among multiple non-invasive therapeutic approaches for critical limb ischemia (CLI), gene therapy has been widely researched because of its capacity to ensure continuous expression and growth factors release. Hypoxia-inducible factor-1α (HIF-1α), a gene that can promote stable angiogenesis and tissue restoration, is a potential candidate for facilitating cellular adaptation to hypoxia during vascular injury recovery. Herein, we designed a near-infrared (NIR) light-propelled pEX-1/HIF-1α plasmid DNA (pDNA) loaded Janus polydopamine@mesoporous silica (PDA@MS) nanomotors (PDA@MS-NH₂@HIF-1α) with asymmetric yolk@shell structure and rough particle surface containing large pores. The PDA@MS nanomotors have a rough and porous particle surface that is modified with positively charged am

SUBMITTER: Gui L 

PROVIDER: S-EPMC12198028 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature