Periplakin Attenuates Liver Fibrosis via Reprogramming CD44^Low Cells into CD44^High Liver Progenitor Cells.

ABSTRACT:

Background & aims

Liver progenitor cells (LPCs) contribute significantly to the restoration of injured liver parenchyma and promote liver regeneration, thereby ameliorating liver fibrosis. However, the mechanism of the derivation of LPCs remains poorly understood.

Methods

We first examined the expression of periplakin (PPL) in patients and mouse models with liver fibrosis. Adenovirus overexpressing PPL was injected into the tail vein of mouse models to detect the regulatory effect of PPL on liver fibrosis. Single-cell sequencing explored how PPL influences liver fibrosis progression. Additionally, PPL⁺CD44^Low cells and PPL⁺CD44^High LPCs were transplanted into 3,5-diethoxycarbonyl-1,4-dihydrocollidine-induced mouse models to assess

SUBMITTER: Zhang L 

PROVIDER: S-EPMC12198045 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature