Mechanistic insights into periodontal ligament stem cell-derived exosomes in tissue regeneration.

ABSTRACT:

Objective

This review comprehensively examined the emerging role of exosomes derived from periodontal ligament stem cells (PDLSC-Exos) in regenerative medicine and dentistry, with a particular focus on their therapeutic potential in periodontitis-a prevalent inflammatory disease characterized by the progressive destruction of periodontal tissues.

Methods

An initial search on Scopus, Web of Science, and PubMed using terms associated with exosomes (i.e., exosomes, exosomal, extracellular vesicles, and EVs) and periodontal ligament stem cells without any limitation of publication year and field of study was performed on October 31st, 2024.

Results

PDLSC-Exos demonstrated significant therapeutic efficacy in both bone and periodontal regeneration as well as various medical

SUBMITTER: Ahmad P 

PROVIDER: S-EPMC12198077 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature