Efficacy and safety of oral Chinese medicine combined with chemotherapy: a systematic review and network meta-analysis.

ABSTRACT:

Background

Non-small-cell lung cancer (NSCLC), a leading cause of global cancer mortality, often presents at advanced stages with limited efficacy from standard chemotherapy. This study evaluated the efficacy and safety of six oral traditional Chinese medicines (TCMs) combined with chemotherapy for NSCLC.

Methods

Following PRISMA-NMA guidelines, a systematic review and network meta-analysis of 36 randomized controlled trials (RCTs, n = 2,846 patients) was conducted. Databases including PubMed, China National Knowledge Infrastructure (CNKI), and Web of Science were searched. Outcomes assessed included objective response rate (ORR), immune markers (CD4-CD8 ratio and natural killer (NK) cells), tumor markers (CA125, carcinoembryonic antigen (CEA), and CYFRA21-1), and adv

SUBMITTER: Ma Y 

PROVIDER: S-EPMC12198167 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature