Identification and Validation of Novel Lipids Linked to Bone Mineral Density Change and Fracture Risk.

ABSTRACT: To identify and validate lipid metabolites associated with bone mineral density (BMD) change and fracture risk through integrated Mendelian randomization (MR) and observational analyses. Two-sample MR analysis was first performed to uncover potential causal relationships between 32 lipid classes and 576 lipid species and BMD and fractures. Identified signatures were subsequently validated in an independent cohort (N = 492), where lipids, BMD, and fracture status were measured at two time points, 8 years apart. The false discovery rate method was employed to control multiple testing. Linear and log binomial mixed-effects models were used to analyze lipid associations with hip BMD and fracture risk, respectively. Two-sample MR revealed seven lipid classes causally associated with BMD and/or

SUBMITTER: Ma C 

PROVIDER: S-EPMC12198305 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature