Predictive goal coding by dentate gyrus somatostatin-expressing interneurons in male mice.

ABSTRACT: To select appropriate behaviour, individuals must rely on encoding of relevant features within their environment in the context of current and past experiences. This function has been linked to goal-associated activity patterns of hippocampal principal cells. Using single-unit recordings from optogenetically identified somatostatin-expressing interneurons (SOMIs) in the dentate gyrus of head-fixed mice trained in a spatial goal-oriented reward-learning task in virtual realities, we show that SOMI activity temporally precedes reward-locations in expert mice characterized by goal-anticipatory behaviour. Predictive goal-encoding by SOMIs is lost after translocation of learned goals to novel previously unrewarded sites leading to rapid reductions in anticipatory behaviour and fast reconfigurat

SUBMITTER: Yuan M 

PROVIDER: S-EPMC12198415 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature