Efficacy of antiobesity medications for weight reduction in older adults: a systematic review.

ABSTRACT:

Objective

The objective of this study was to examine weight reduction and adverse events associated with use of antiobesity medications (AOMs) in older adults ages ≥65 years.

Methods

Seven databases were searched for studies evaluating weight reduction of Food and Drug Administration (FDA)-approved AOMs. Studies had to include adults ages ≥65 years with obesity (BMI ≥ 30 kg/m² or ≥27 kg/m² with one weight-related condition), with independent analysis of weight reduction for adults ages ≥65 years. Two coauthors extracted and evaluated studies for risk of bias using standardized forms.

Results

Six experimental studies (five secondary analyses of randomized clinical trial data and one single-arm trial) and two observational studies met inclusion cri

SUBMITTER: Chen AS 

PROVIDER: S-EPMC12198421 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature