STOX1 Isoform A Promotes Proliferation and Progression of Hepatocellular Carcinoma by Dual Mechanisms of Transcriptionally Upregulation of Cyclin B1 and Activation of ROS-Dependent PTEN/AKT1 Signaling.

ABSTRACT:

Background

Dysregulation of transcription factors is one of the most common factors for the pathogenesis of hepatocellular carcinoma (HCC). To the best of our knowledge, no study has yet investigated the clinical significance and functional role of STOX1 in HCC.

Methods

Real-time PCR, Western blotting and immunohistochemistry were performed to examine the expression of STOX1-A in HCC specimens. Animal experiment in vivo and functional cell assays in vitro were used to investigate the tumorigenic and proliferative ability of HCC cells. Luciferase and ROS assays were depolyed to investigate the molecular mechanisms underlying the biologic role of STOX1-A in HCC.

Results

In this study, we report that STOX1 isoform A (STOX1-A) is significantly upregulated in HCC tissues,

SUBMITTER: Jiang C 

PROVIDER: S-EPMC12198656 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature