Synthesis and Evaluation of Novel Bis-Chalcone Derivatives Containing a Thiophene Moiety as Potential Anticancer Agents: In Vitro, In Silico , and Mechanistic Studies.

ABSTRACT: Chalcone compounds have demonstrated potent anticancer activities in the past few decades with few adverse consequences. Using Claisen-Schmidt condensation, two new series of bis-chalcone derivatives (5a-c and 9a-c) bearing the thiophene moiety have been designed and generated. All compound structures were examined and elucidated by spectroscopic investigations. The MTT assay, gene expression assay, cell cycle analysis, apoptosis assay, Western blotting analysis, zymographic analysis, and molecular docking were used to evaluate the anticancer efficacy of the synthesized compounds against breast, colon, and lung cancer cells. Out of the two synthesized series, four compounds (5a, 5b, 9a, and 9b) showed significant cytotoxic effects aga

SUBMITTER: Fathi EM 

PROVIDER: S-EPMC12198996 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature