Artificial Intelligence-Powered Spatial Analysis of Immune Phenotypes in Resected Pancreatic Cancer.

ABSTRACT:

Importance

Although tumor-infiltrating lymphocytes (TILs) have been implicated as prognostic biomarkers across various malignancies, the clinical application remains challenging. This study evaluated the applicability of artificial intelligence (AI)-powered spatial mapping of TIL density for prognostic assessment in resected pancreatic ductal adenocarcinoma (PDAC).

Objective

To evaluate the prognostic significance of AI-powered spatial TIL analysis in resected PDAC and its clinical applicability.

Design, setting, and participants

This cohort study included patients with PDAC who underwent up-front R0 resection at a tertiary referral center between January 2017 and December 2020. Whole-slide images of retrospectively enrolled patients with PDAC and up-front R0 resectio

SUBMITTER: Kim H 

PROVIDER: S-EPMC12199178 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature