Nickel-catalyzed diastereoselective hydroboration of acrylates with a vinylborane reagent.

ABSTRACT: Organoboron compounds exhibit unique properties and valuable applications in organic synthesis, catalysis, materials science, and drug discovery, driving researchers to improve their structural and functional diversity. Despite significant advancements, challenges remain in accessing complex organoboron compounds, particularly in constructing boron-stereogenic skeletons. Here we report a nickel catalyzed diastereoselective hydroboration of olefins using a newly developed vinylborane reagent, CH₂[double bond, length as m-dash]CH-BH₂L (where L is a dative donor). This protocol enables the efficient synthesis of versatile vinylborane derivatives featuring a boron-stereogenic center. Mechanistic studies, including the isolation and structural characterization of a key B-H

SUBMITTER: Hu G 

PROVIDER: S-EPMC12199273 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature