Isolation, structural elucidation, and integrated biological and computational evaluation of antidiabetic labdane diterpenes from <i>Curcuma zedoaria</i> rhizomes.

ABSTRACT: The phytochemical investigation of the EtOAc-soluble extract of the rhizomes of Curcuma zedoaria (Berg.) Roscoe led to the isolation of five labdane-type diterpenes, including a previously undescribed norditerpene, zedolabdin A (CZ1), and four known compounds (CZ2-CZ5). The structures of these compounds were elucidated using NMR, HR-ESI-MS, and IR spectroscopy, supported by comparisons with literature data. The anti-α-glucosidase evaluation revealed that all compounds exhibited potent inhibitory activity, with zerumin (CZ3) and coronarin C (CZ4) displaying the most potent inhibition, achieving IC₅₀ values of 6.2 μM and 3.0 μM, respectively, significantly lower than the positive control, acarbose (IC₅₀ = 190.6 μM). Molecular docking and dynamics studies identifi

SUBMITTER: Le TH 

PROVIDER: S-EPMC12199309 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature