Injectable and Sprayable Thermoresponsive Hydrogel with Fouling-Resistance as an Effective Barrier to Prevent Postoperative Cardiac Adhesions.

ABSTRACT: Postoperative adhesions are inevitable consequences of surgery, resulting in various complications. The risk increases, particularly in cardiac surgery, where reoperations or staged operations are in high demand. The presence of cardiac adhesions severely complicates resternotomy procedures, which may increase the risk of re-traumatizing, bleeding, operation time extension, and even mortality. Here, a biodegradable thermo-sensitive fouling-resistant hydrogel based on poly(D,L-lactide)/poly(ethylene glycol) (PLEL) micelles is developed, exhibiting high compatibility with both thoracotomies and minimally invasive interventions. By combining the advantages of liquid and film barriers, this hydrogel can completely cover irregular wounds after injecting or spraying and fully avoid direct contac

SUBMITTER: Shi K 

PROVIDER: S-EPMC12199412 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature