Incidence trends and disparities in infection-related malignancies of the liver among US adults, 2000-2019.

ABSTRACT:

Background

Trend analysis in infection-related malignancy of the liver is still limited. We aimed to evaluate the incidence trend in hepatocellular carcinoma (HCC), intrahepatic cholangiocarcinoma (iCCA), combined hepatocellular carcinoma and cholangiocarcinoma (cHCC-CCA), and primary hepatic lymphoma (PHL) in the USA during 2000-2019.

Method

In this population-level study, cases of HCC, iCCA, cHCC-CCA, and PHL from the Surveillance, Epidemiology, and End Results (SEER) registries during 2000-2019 were included. The average annual percentage change (AAPC) in 2000-2019 was computed to describe the age-adjusted incidence trends for each disease and was stratified by demographic and geographic variables.

Results

HCC and iCCA incidence increased from 5.51 (per 100,000 per

SUBMITTER: Zou Z 

PROVIDER: S-EPMC12199910 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature