Persistent pain signaling and stress response in a mouse model of inflammatory low back pain.

ABSTRACT:

Introduction

Chronic low back pain (LBP) is linked to dysfunction in both peripheral and central nervous systems and is a risk factor of psychiatric disorders such as depression. However, pain-related signaling in sensory and central neurons during chronic LBP, and its impact on stress-induced emotional behaviors, remains poorly understood.

Objectives

The aim of this study was to investigate persistent changes in pain-related and inflammation-related signaling in an inflammatory LBP mouse model and assess its influence on stress-related behaviors.

Methods

An LBP-like condition was induced by administering complete Freund adjuvant to the lumbar region in mice. Behavioral assessments included gait analysis and mechanical sensitivity testing. Gene expression and immunohi

SUBMITTER: Motohashi H 

PROVIDER: S-EPMC12200223 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature