Progression and natural history of Atypical Parkinsonism (ATPARK): Protocol for a longitudinal follow-up study from an underrepresented population.

ABSTRACT:

Background

Atypical Parkinsonian Syndromes (APS) form the third largest group of neurodegenerative disorders including Progressive Supranuclear Palsy (PSP), Multiple System Atrophy (MSA), and Corticobasal Syndrome (CBS). These conditions are characterized by rapid progression, poor prognosis, low survival rates, and limited treatment options. Few studies have suggested that genetic, environmental factors and inflammation contribute to the pathobiology of these complex disorders, however, the etiology of disease and progression remains unclear.

Methods

A multicenter prospective longitudinal (3-time point) study will be conducted with a total sample size of 400 across all the groups (PSP, MSA, CBS). Patients with APS will be recruited after a detailed evaluation by movement di

SUBMITTER: Yadav R 

PROVIDER: S-EPMC12200670 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature