Effects of Conocarpus lancifolius and crocin on superoxide dismutase and protein kinase B genes and protein expressions in diabetic rats.

ABSTRACT:

Background

Diabetes mellitus, characterized by chronic hyperglycemia, is a global health challenge. Effective management strategies often focus on improving insulin sensitivity and enhancing antioxidant defenses to mitigate diabetes-related complications. This study explored the therapeutic potential of Conocarpus lancifolius (Co) and crocin in modulating insulin signaling and antioxidant gene expression in diabetic rats.

Methods

Male Wistar rats were rendered diabetic via alloxan injection and treated orally with C. lancifolius and crocin. Control groups included normal healthy control and untreated diabetic rats. Insulin signaling pathways were assessed by measuring key markers such as protein kinase B (AKT) through western blot and RT-PCR analysis. Antioxidant gene expres

SUBMITTER: Lotfy M 

PROVIDER: S-EPMC12200675 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature