Using computer-generated protein models to analyze mutations linked to Amelogenesis Imperfecta.

ABSTRACT: Amelogenesis Imperfecta (AI) is a disorder of tooth development caused by mutations in genes involved in several stages of tooth enamel formation. Few proteins involved in tooth development or developmental anomalies are explored in detail. Knowledge of 3D protein structure is essential to studying protein function. However, crystallized complete protein structures related to teeth and oral development are rare in the Protein Data Bank. Computational approaches for automated protein structure prediction have become a popular alternative for generating protein 3D structures. In this study, we aimed to explore the potential of using computer-generated protein models to analyze mutations linked to AI. We took a systematic approach to identify, screen, and analyze AI-linked protein variants. P

SUBMITTER: Sharmin N 

PROVIDER: S-EPMC12200857 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature