Recovery of retinal terminal fields after traumatic brain injury: evidence of collateral sprouting and sexual dimorphism.

ABSTRACT: The central nervous system is characterized by its limited regenerative potential, yet striking examples of functional recovery after injury in animal models and humans highlight its capacity for repair. Little is known about repair of pathways/circuits after traumatic brain injury (TBI), which results in disruption of connectivity. Here we utilize a mouse model of diffuse traumatic axonal injury (Impact-acceleration TBI) in order to explore, for the first time, the evolution of structural and functional changes in the terminal fields of the injured visual system. Retinal ganglion cell (RGC) axons and synapses were genetically labeled via AAV transduction, while anterograde and transsynaptic tracers were used to mark terminals and postsynaptic cells. Functional connectivity and visual inte

SUBMITTER: Alexandris AS 

PROVIDER: S-EPMC12201153 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature