From moderate to strenuous training: unravelling mechanistic contributors and biomarkers for atrial fibrillation in exercise.

ABSTRACT:

Aims

The impact of the transition from moderate to strenuous exercise on atrial fibrillation (AF) risk and its underlying mechanisms remain poorly understood. We aimed to analyse biatrial remodelling after moderate and strenuous exercise, compare it with pathological atrial damage, and non-invasively identify strenuous exercise insults.

Methods and results

Young male Wistar rats were trained at a moderate (MOD) or high-intensity (INT) load; sedentary rats served as controls. After 16 weeks, electrophysiological and echocardiographic studies were obtained, and atrial samples were used for fibrosis quantification. Plasmatic biomarkers (at rest and after exercise) and atrial gene expression (mRNA array) were assessed. Results were compared with a transverse aortic constriction

SUBMITTER: Alcarraz A 

PROVIDER: S-EPMC12202093 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature