Clinical Characteristics of Patients With Enlarged Ventricles and Cognitive Impairment (EVCI): Case Series.

ABSTRACT:

Background

Since research on the pathophysiology of psychiatric disorders diagnosed by symptoms has not succeeded, a data-driven analysis incorporating biological and cross-disease perspectives has been proposed. We have reported a new subgroup of psychiatric disorders by a data-driven analysis of subcortical volumes of brain MRI in 5602 subjects, including patients with psychiatric disorders and controls. This subgroup of patients is characterized by enlarged ventricle and cognitive impairment (EVCI) with a high proportion of schizophrenia, electroencephalography abnormalities, and rare pathological copy number variations.

Case presentation

Of the nine patients with EVCI, eight patients had schizophrenia, and one patient had autism spectrum disorder. Early onset of age was

SUBMITTER: Yasuda Y 

PROVIDER: S-EPMC12202129 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature