Combined effects of <b>β</b>-hydroxybutyrate and therapeutic hypothermia in a neonatal hypoxia-ischemia model.

ABSTRACT: Hypoxia-ischemia (HI) is one of the leading causes of brain damage during the development of newborns. It can result in death or cause varying degrees of neurological disability. The only well-established treatment currently available for neonatal HI is therapeutic hypothermia (TH). However, TH is only partially protective, reducing severe disability by approximately 11%. Therefore, new therapeutic approaches are urgently needed. It is known that immature brains utilize higher levels of ketone bodies, such as β-hydroxybutyrate (BHB), that may contribute to resistance to hypoxic-ischemic events. In this study, 11-day-old animals were subjected to the neonatal HI (Rice-Vannucci model) and treated with TH alone or in combination with BHB administration. To assess brain metabolism, glucose upt

SUBMITTER: Fabres RB 

PROVIDER: S-EPMC12202384 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature