Comparative transcriptome and metabolome profiling unveil genotype-specific strategies for drought tolerance in cotton.

ABSTRACT: As a globally important economic crop, cotton often faces yield and quality limitations due to drought stress. To elucidate drought tolerance mechanisms, this study screened a drought-tolerant variety (64-22-3) and a drought-sensitive variety (Anmian 3, A3) from five drought-resistant and five drought-sensitive materials, respectively. Integrated transcriptomic and metabolomic analyses revealed 7,351 differentially expressed genes (DEGs) in the drought-tolerant variety under drought treatment (5,034 upregulated, 2,317 downregulated), while the drought-sensitive variety exhibited 5,009 DEGs (3,222 upregulated, 1,787 downregulated). Metabolomic profiling identified 169 differentially accumulated metabolites (DAMs) (120 upregulated, 49 downregulated) in 64-22-3 and 173 DAMs (120 upregulated,

SUBMITTER: Han A 

PROVIDER: S-EPMC12202649 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature