A novel histological occlusion classification for coiled aneurysms based on multiphoton microscopy.

ABSTRACT: ObjectiveIntracranial aneurysm (IA) coiling remains the most commonly used endovascular approach for ruptured and unruptured IA, and recanalization is a common drawback that impairs treatment success. Angiographic occlusion and aneurysm healing are not synonymous, and histological evaluation of embolized aneurysms remains a challenge. We propose here an experimental study of coil embolization in animal models by multiphoton microscopy (MPM) in comparison with conventional histological staining. The purpose of his work is to analyze coil healing process using histological sections of aneurysms.MethodsBased on a rabbit elastase model, 27 aneurysms were fixed, embedded in resin, and cut in thin histological sections 1 month after coils implantation and after angiographic control. Hematoxylin

SUBMITTER: Zoltan S 

PROVIDER: S-EPMC12202903 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature