Stereoselective chemoenzymatic phytate transformations provide access to diverse inositol phosphate derivatives.

ABSTRACT: Phosphorylated myo-inositols (InsPs) are essential cytoplasmic signaling molecules, while their lipidated analogs (PtdInsPs) play a crucial role in membrane signaling. Stereoselective synthesis of these compounds has been achieved through various methods, predominantly using the meso compound myo-inositol as a starting material. However, phytate (InsP₆), also a meso compound, is the most abundant inositol derivative in plants - far more prevalent than myo-inositol itself. Despite its abundance, phytate has been rarely used in synthetic strategies for accessing a variety of chiral inositol phosphates and their derivatives through selective dephosphorylations on a preparative scale. Here, we report gram-scale (stereo)selective dephosphorylations

SUBMITTER: Haner GM 

PROVIDER: S-EPMC12203238 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature