Prematurity is associated with white matter T2 MRI visible perivascular spaces in very preterm-born neonates.

ABSTRACT: Perivascular spaces (PVSs), as biomarkers of the brain's neurofluid clearance system, remain largely unexplored in the brains of very preterm and term-born infants. In this retrospective cross-sectional study, we investigate PVSs in very preterm and term-born neonates and explore potential associations with preterm birth, maturation, brain injury and developmental outcome. T2-weighted fast spin echo MRI data of 86 very preterm (<32 gestational weeks) and 43 term-born neonates were acquired at term-equivalent age (mean postmenstrual age = 41.63 ± 2.09 weeks) with a 3T GE HD.xt scanner, using an 8-channel head coil, with echo time/repetition time = 109/5700 ms, field of view = 25.6 cm, acquisition matrix = 256 × 256, reconstruction matrix = 512 × 512 and slice thickness = 2 mm. PVS counts we

SUBMITTER: Meinhold L 

PROVIDER: S-EPMC12203554 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature