Isomerization of Poly(ethylene glycol): A Strategy for the Evasion of Anti-PEG Antibody Recognition.

ABSTRACT: PEGylation, the conjugation of poly(ethylene glycol) (PEG) to nanocarriers or protein-based active pharmaceutical ingredients (APIs), is a key strategy in nanomedicine to extend the circulation time of therapeutics in the bloodstream based on the stealth effect of PEG. However, the growing prevalence of anti-PEG antibodies in the population can lead to pronounced immune responses upon drug administration and accelerated blood clearance of PEGylated drugs, resulting in the loss of the stealth effect. We introduce the randomized PEG (rPEG) technology designed to strongly reduce the antigenicity of PEG while preserving its core benefits. This conceptually novel approach is based on an introduction of hydrophilic side chains along the PEG backbone. The synthesis is performed via anionic ring-o

SUBMITTER: Dreier P 

PROVIDER: S-EPMC12203584 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature