A Proteogenomic View of Synchronous Endometrioid Endometrial and Ovarian Cancer.

ABSTRACT:

Purpose

Increasing genomics-based evidence suggests that synchronous endometrial and ovarian cancer (SEOC) represents clonally related primary and metastatic tumors. A systematic analysis of the global protein landscape of SEOCs, heretofore lacking, could reveal functional and disease-specific consequences of known genetic alterations, the directionality of metastasis, and accurate histologic markers to distinguish SEOCs from single-site tumors.

Experimental design

We performed a systematic proteogenomic analysis of 29 patients diagnosed with SEOC at three international gynecologic oncology treatment centers (Chicago, Vancouver, and Tübingen). For direct comparison with single-site tumors, we included 9 patients with single-site endometrioid ovarian and 26 patients with sing

SUBMITTER: Coscia F 

PROVIDER: S-EPMC12203618 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature