Antitrypanosomal potential of Salvia officinalis terpenoids-rich fraction in Trypanosoma evansi-infected rat model.

ABSTRACT: BACKGROUND TRYPANOSOMA EVANSI : (T. evansi) is a major protozoan disease that affects animals, including camels, and causes substantial economic detriments. The failure to control T. evansi infections is due to the unavailability of vaccines and the development of resistance to existing chemical drugs. In this study, we evaluated the effect of Salvia officinalis terpenoids-rich fraction on the degree of parasitemia and associated pathological alterations in rats experimentally infected with T. evansi.

Method

Eighty adult male rats were equally divided into 4 groups. The first group was a negative control. The second group was intraperitoneally infected with T. evansi at a dose of 1 × 10⁴ trypanosomes. The third group was similarly infected and subsequently treated intramu

SUBMITTER: Sawerus MG 

PROVIDER: S-EPMC12203732 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature