Heritable Tissue-Specific Gene Expression Associates With Chronic Wound Microbial Species.

ABSTRACT: The reasons for interpatient variability in chronic wound microbiome composition are thought to be complex but are poorly known. To investigate how patients' genetically regulated tissue expression may influence chronic wound bacterial composition, we performed a microbiome-transcriptome-wide association study. This approach involved estimating for 509 patients their tissue-specific gene expression from DNA genotypes, followed by associating gene expression to the relative abundances of species detected in their wounds as provided on clinical reports to the physician. Comparisons to artery, blood, fibroblast, skeletal muscle, skin, subcutaneous fat, and nerve tissue resulted in 251 transcriptional differences at 109 genes significantly explaining abundances of 39 different species. Overall

SUBMITTER: Omeir K 

PROVIDER: S-EPMC12203766 | biostudies-literature | 2025 Jul-Aug

REPOSITORIES: biostudies-literature