A subset of evolutionarily conserved centriolar satellite core components is crucial for sperm flagellum biogenesis.

ABSTRACT: Rationale: Centriolar satellites are non-membranous cytoplasmic granules that cluster around centrosomes, with pericentriolar material 1 (PCM1) serving as the molecular marker for these structures. Although significant progress has been made in understanding their composition, cellular, and organismal functions over the past decades, the tissue-specific roles of centriolar satellite proteins in sperm flagellum biogenesis and male fertility are still not well understood. Methods: We utilize publicly available data and conduct phylogenetic analysis to explore the tissue distribution and conservation of centriole satellite components across flagellated species. Knockout mouse models for Ccdc13 and Pcm1 were constructed to investigate their physiological roles. Sper

SUBMITTER: Wu B 

PROVIDER: S-EPMC12203921 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature