Elucidation of roles of serine/threonine phosphatases PP1 and PP2A in mediating CCK-stimulated growth and enzyme secretion in pancreatic acinar cells.

ABSTRACT: Serine/threonine phosphatases, protein phosphatases 1 and 2A (PP1 and PP2A), play important roles in mediating cellular signaling in different tissues to different stimuli, including glycogen metabolism, protein synthesis/growth, and secretion. However, the roles of PP1/PP2A in pancreatic acinar cell secretion/growth are both unclear and controversial. To address this issue, in the present study, we examined the ability of gastrointestinal hormones/growth factors (GFs) to activate PP1 and PP2A and the signaling cascades involved in rat pancreatic acini and the pancreatic acinar tumor cell line, AR42J cells. PP1 and PP2A were both detected in pancreatic acini and AR42J cells. In acini, PP1 and PP2A were activated by pancreatic secretagogues-stimulating phospholipase C (bombesin, CCK-8, and

SUBMITTER: Ramos-Alvarez I 

PROVIDER: S-EPMC12203987 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature