Cell-Derived Epigenomic Markers of Chronic Stress Distinguish Breast Cancer Phenotypes.

ABSTRACT: Breast cancer (BC) is a highly prevalent malignancy in women and is often resistant to available therapies, calling for urgent investigation of the molecular mechanisms underlying its pathogenesis and progression. BC is thought to result from a complex interplay between genetic and environmental factors. Among key factors, chronic stress has been associated with worse cancer outcomes and can profoundly impact the epigenome. However, both stress and BC phenotypes are complex and heterogeneous, making studies that examine their molecular links challenging. Despite their heterogeneity, stressors trigger a neuroendocrine response that in humans culminates in the release of cortisol, a highly lipophilic hormone that traverses essentially every cell and induces widespread genomic effects. Modeli

SUBMITTER: Acharya A 

PROVIDER: S-EPMC12204029 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature