MiR-381-3p contribution in mouse spontaneous abortion <i>via</i> targeting VEGFA.

ABSTRACT:

Background

Recurrent spontaneous abortion (RSA) affects 1-5% of pregnant women; however, the mechanisms underlying this condition remain unknown. Dysangiogenesis in the placenta is an essential factor in the pathogenesis of RSA. Studies have verified that microRNAs (miRNAs) are vital for RSA; however, their mechanism of action in regulating angiogenesis remains unclear. Therefore, we explored the contribution of key miRNAs that regulate angiogenesis in RSA.

Methods

The abortion mouse model was constructed by intraperitoneal injection of beta2-Glycoprotein I (β2-GPI). The abnormal expression of miRNAs in the placenta of the abortion mice was screened using miRNA-seq. Based on miRNA databases, miR-381-3p, which is highly expressed in abortion mice, may bind to vascular endothe

SUBMITTER: Ding C 

PROVIDER: S-EPMC12204090 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature