VIRMA-mediated m⁶A modification regulates forebrain formation through modulating ribosome biogenesis.

ABSTRACT: N⁶-Methyladenosine (m⁶A) modification plays crucial roles in tissue development and homeostasis. However, the mechanisms underlying cellular adaptation of m⁶A modification and their impact on protein synthesis machinery remain unclear. VIRMA, the largest and evolutionarily conserved core of the m⁶A methyltransferase complex, is highly expressed in the embryonic brain and various cancers. Here, we demonstrate that VIRMA-mediated m⁶A modification is essential for active ribosome biogenesis. VIRMA depletion destabilizes the entire writer complex and reduces m⁶A levels, leading to decreased proliferation and increased apoptosis of neural progenitor/stem cells, ultimately causing severe forebrain developmental defects. Mec

SUBMITTER: Wu M 

PROVIDER: S-EPMC12204135 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature