Vaginal microbiome composition in women with HIV undergoing treatment of cervical transformation zone in a screen and treat program in Zambia.

ABSTRACT: This study assessed the vaginal microbiome in women with HIV undergoing cervical transformation zone treatment in Zambia. 16S rRNA sequencing showed lower microbial diversity in successful outcomes (N = 18) than those with treatment failure (N = 17) treatment outcome, with Lactobacillus abundance correlated with success. Moreover, HPV-negative women (N = 12) had higher Lactobacillus levels and less pathogens than HPV-positive women (N = 12). These findings suggest a Lactobacillus-dominated microbiome may be associated with positive treatment outcomes.

SUBMITTER: Pinder LF 

PROVIDER: S-EPMC12204225 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature