Cell type-specific associations with Alzheimer's Disease conserved across racial and ethnic groups.

ABSTRACT: Genomic studies at single-cell resolution have implicated multiple cell types associated with clinical and pathological traits in Alzheimer's Disease (AD), but have not examined common features across broad, multi-ethnic populations, and across multiple regions. To bridge this gap, we performed single-nucleus RNA-seq and ATAC-seq profiling of cortical and subcortical brain regions from post-mortem samples across Non-Latin White, African American, and Latin donors (the latter of any race). Using discrete and continuous dissection of molecular programs, we elucidate cell-type-specific glial and neuronal signatures associated with AD across multiple population groups. Notably, we found that multiple microglial (GPNMB+, CD74+, and CR1+ subgroups) and astrocyte (SERPINH1

SUBMITTER: Luquez T 

PROVIDER: S-EPMC12204241 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature