Deep brain stimulation-induced local evoked potentials outperform spectral features in spatial and clinical STN mapping.

ABSTRACT:

Objective

Deep brain stimulation (DBS) of the subthalamic nucleus (STN) is an established therapy for Parkinson's Disease (PD). Yet, optimizing lead placement and stimulation programming remains challenging. Current techniques rely on imaging and intraoperative microelectrode recordings (MER), while programming rely on trial-and-error clinical testing, which can be time-consuming. DBS-induced local evoked potentials (DLEP), also known as evoked resonant neural activity (ERNA), have emerged as a potential alternative electrophysiological marker for mapping. However, direct comparisons with traditional spectral features, such as beta-band, high-frequency oscillations (HFOs), and aperiodic component have been lacking.

Approach

We evaluated DLEP across 39 STN DBS leads across 31

SUBMITTER: Opri E 

PROVIDER: S-EPMC12204254 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature