Parity modifies the effect of genetic variants associated with gestational duration and birth weight.

ABSTRACT: Gestational duration and birth weight are linked to both short- and long-term adverse health outcomes in mothers and their offspring. Previous genome-wide association studies on these pregnancy outcomes have been successful but have overlooked the number of a mother's previous pregnancies. In this study, we explored if parity (the number of children a mother has previously delivered) modifies the maternal or foetal genetic effect of gestational duration and birth weight (gene × parity interactions) using data from the Norwegian Mother, Father, and Child Cohort Study in up to 58,528 mothers and their offspring. Potential genetic effect differences were investigated by: (1) performing parity-stratified genome-wide association studies, (2) testing SNP × parity interactions, (3) testing the in

SUBMITTER: Ytterberg K 

PROVIDER: S-EPMC12204269 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature